Advanced Course

Modelling and Computation for Micro-organisms in Bioprocesses

New date a.s.a.p.

Course introduction

This course brings together contributions from different disciplines: bioprocess technology, applied physics, transport phenomena, molecular biology and biomedical sciences. They all address different elements on the coupling between several time and length scales in the simulation of different bioprocesses (e.g. bioreactor and bioprocess operation, microbial strain improvement, tissue and organ cultivation, plant design and integration). Computational methods will deepen the understanding of the connecting principles between different scales.

The idea of this course is to move from large-scale industrial bioprocesses (hectometers/days) down to the intracellular level (nanometers/microseconds), through several intermediate scales. These intermediate scales describe details inside the bioreactor (meters/hours) and in multicellular aggregates, as e.g. appearing in biofilms or tissues (millimeters/seconds). Top-down approaches allow answering particular questions in a natural way: a quantitative understanding at a higher level will – due to progressing insight or new requirements – be enhanced by details revealed by smaller scales approaches. A higher resolution description of the system will require a greater experimental effort to identify mechanisms and parameter values, together with considerably larger computational expenses. With the material presented in the course, the participants will better grasp the complexity of multileveled systems based on the underlying mechanisms. The increasing power of computational methods and hardware drastically reduces the need for simplification and thereby enhances the predictive capabilities of numerical models and our level of process understanding. This trend is expected to further develop at high pace.

2 - 6 December 2024
Delft University of Technology, the Netherlands

Advanced Course Modelling and Computation for Micro-organisms in Bioprocesses

Programme

  • Industrial bioprocess design, integration and flowsheeting
  • Gradients (concentration, shear rate, temperature) in bioreactors coupled to dynamic microbial response and compartmented kinetic models
  • Industrial fermentation models with computational fluid dynamics and reaction dynamics by Euler-Lagrange approach and cell lifelines
  • Micro-gradients in multicellular aggregates (biofilms, granules, tissues)
  • Single-cell models including membrane transport, metabolic variation, intracellular dynamics and genetic diversity

Advanced Course Modelling and Computation for Micro-organisms in Bioprocesses

Who should attend?

The course is primarily aimed at academic and industrial specialists (MSc, PhD or equivalent experience) who seek broadening their knowledge and practical skills in multiscale modelling. Educational background in transport phenomena, basic reaction engineering and biotechnology is strongly advised. Affinity with biological systems is recommended.

Advanced Course Modelling and Computation for Micro-organisms in Bioprocesses

Fee

*To be eligible for the reduced early bird fee you need to register before 23 September 2024. If this date is exceeded, the regular fee applies.

**A limited number of fellowships is available for PhD students and SME’s (small/medium enterprise). Fellowships will be available on a first-come-first-serve basis. To apply as to one of these fellowships, please include a copy either of your registration as a PhD student from your university or a proof of the SME-status of the company you work at.

The fee includes course materials, lunches and the buffets and the course dinners as indicated on the program. The fee does not cover other meals or lodging.

The course fee

Early bird*

€ 3.000,-

Regular fee

€ 3.250,-

Small and medium-sized enterprises (SME/Startups/scaleups)**

€ 2.250,-

Small and medium-sized enterprises (SME/Startups/scaleups) of Biotech Campus Delft**

€ 1.750,-

PhD Students**

€ 1.750,-

Advanced Course Modelling and Computation for Micro-organisms in Bioprocesses

Course board members

Prof.dr.ir. Henk Noorman

Board member

Dr.ir. Adrie Straathof

Board member

Dr.ir. Cees Haringa

Board member

Prof.dr. Cristian Picioreanu

Board member

Advanced Course Modelling and Computation for Micro-organisms in Bioprocesses

Downloads

Advanced Course Modelling and Computation for Micro-organisms in Bioprocesses

Register

After registration you will receive a confirmation e-mail from us and another email with an invoice. We look forward to welcoming you in our course in Delft!

Note

A limited number of fellowships is available for PhD students (reduced fee). Deadline for registration is 11 November 2024.

Advanced Course Modelling and Computation for Micro-organisms in Bioprocesses

Register

Advanced Course Modelling and Computation for Micro-organisms in Bioprocesses

Testimonials

‘A fantastic way to explore the modelling approaches’

Christoff Odendaal

PhD student, University Medical Centre Groningen I am a molecular systems biologist focusing on biomedical applications but I was interested in learning more about the use of computational techniques in industry and biotechnology. This course was a fantastic way to explore the modelling approaches used for wide array of biotechnology applications as well as the underlying theory. Read more
‘A good balance between theoretical lectures and software practice’

Elco Backus

Janssen vaccines and prevention, Senior associate scientist Process development Having attended the Bioprocess design course in 2017, I have had good experiences with the advanced courses provided by BioTech Delft / TU Delft. My expectation was that I would gain more knowledge on computational modelling applications surrounding bacterial fermentation like computational fluid dynamics (CFD) and how this is applied. Read more
‘A perfect blend of interaction and knowledge sharing between organizers and participants’

Soumendu Dasgupta

Denmark Technical University, Postdoc at Novo Nordisk Foundation Centre for Biosustainability I am from a Chemical Engineering background with experience in CFD modeling during my PhD and started as a Postdoc at the Novo Nordisk Foundation Centre for Biosustainability for scale down studies of bioreactors. The extensive course was a perfect balance of modeling and experimental techniques Read more
‘You learn to build the models and do the simulation during the course’

Joost Beekman

Senior Scientist Integrated Processing, DSM Food Specialties I have been out of science details for the last 8 years. The Advanced Course Multiscale Computational Methods in Bioprocesses brought me up to speed quickly with many aspects of the rapidly developing fields of modelling and computation. The course shows how different aspects in a biotechnology process can be described adequately Read more
‘Insight into the opportunities and possibilities of modelling used in CFD’

Susanne Gitlesen

Special advisor, NORCE Norwegian Research Centre AS I attended the course to get up to date with current status in modelling of fermentation based processes. My aim was to get a good enough understanding of the different software and model methods to be able to communicate and be a link between biochemists and engineers. I got a good start with this course. Read more
‘I expected a deep and objective course, and it met my expectations’

Henrique Pereira

PhD fellow, Technological University of the Shannon Midlands, Ireland My current career goals demanded a deeper understanding of the state-of-the-art bioprocesses, and I found in the MCMB a potential pathway to achieve this. Read more
‘The course covered all scales from micro to industrial’

Michael Sebakka

Chemical engineering technologist, MicroHarvest GmbH I was interested in enrolling for this course to gain information and tools necessary for modelling to gain insight into my work and accelerate my workflow. Read more